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The management of NCDs can be influenced by the interaction between enzymatic and non-enzymatic antioxidants in food (Table 2)

An intestinal enzyme breaks it down before it reaches your cells, rendering traditional supplements ineffective

Available from: Biaggioni I (2024): Adrenoceptor Agonists & Sympathomimetic Drugs (Chapter 9)

This further confirms that the enhancement of Nrf2 is a viable strategy for activating the GSH system

Gene variants on genes such as MTHFR encoding methylenetetrahydrofolate reductase, MTR encoding methionine synthase, MTRR encoding methionine synthase reductase and CBS encoding cystathionine-B synthase in the methylation pathway can lead to a decreased ability to create sufficient methyl donor (SAMe) and may lead to disruptions in the SAMe:SAH ratio, thus altering methylation capacity and epigenetic regulation