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NO donors such as sodium nitroprusside and S -nitrosoglutathione promote S -nitrosylation at the Cys183 residue of extracellular signal-regulated kinase 1/2 (ERK1/2), which leads to inducing apoptosis in U251 glioma cells (70)
This was one of the goals of its design, leading to a longer half-life in laboratory settings
Upon binding to this target, the compound is studied for its ability to initiate cellular signaling processes
Eventually, Jillian began training clients for real, but it felt like a stopgap rather than a long-term plan