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But when the mice were given broad-spectrum antibiotics that depleted their microbiome, they gained much less weight after undergoing smoking cessation, staying slim for months regardless of their diet

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This perspective hinges on the fact that psychoactive substances have different effects on different brains, underpinning individual differences in mental health and illness ( People suffering from TUD and other mental disorders present a particularly difficult challenge as they represent a highly heterogeneous population with clear clinical subcategories and expectedly different treatment trajectories

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