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Nicotine seems to alternate between acting as a stimulant and a depressant

Results In adjusted within-individual comparisons, relative to periods in which they did not receive ADHD medication, male patients had 35% lower odds of concurrent substance-related events when receiving medication (odds ratio [OR] = 0.65, 95% CI, 0.64-0.67), and female patients had 31% lower odds of concurrent substance-related events (OR = 0.69, 95% CI, 0.67-0.71)

Matt Cooper Tue, Jan 25, 2011 : 5:25 a.m

If you've been chewing tobacco for years or consume large quantities, it's likely that your body has become heavily dependent on nicotine, which can make quitting a more challenging process

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However, nicotine could be easily absorbed through the mucosal lining of oral cavity [2]