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Since 5-HT 1A Rs are located both pre- and post-synaptically (45), we compared the behavioral effects of two antagonists with differing pharmacological profiles to determine which 5-HT 1A Rs mediated adolescent fluoxetine and nicotine effects

In February 2008, the FDA issued a statement which suggested that their evaluation indicates it is increasingly likely that there may be an association between Chantix and serious neuropsychiatric symptoms. In July 2009, the FDA required Pfizer to add a prominently displayed boxed warning about the risk of behavior changes, depression, hostility and suicidal thoughts, which is the strongest warning that can be placed on a prescription medication

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