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In this perspective, we present evidence demonstrating maladaptive cardiac remodeling in nicotine-exposed mice undergoing hemodynamic stress with angiotensin (Ang)-II infusion and review preclinical literature linking nicotine and novel tobacco products with cardiac remodeling and dysfunction

In the first three-and-a-half years the program spent $116 million on tobacco control and health projects including $43 million on a mass-media antismoking campaign

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