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doi: 10.1136/bmjopen-2022-065186 201 WangL.LiaoY.YangR.ZhuZ.ZhangL.WuZ.et al

Combustion produces tar and carbon monoxide, absent in pouches, yet smokers absorb only 1-2 mg per cigarette inefficiently.pmc.ncbi.nlm.nih+1 Vaping alternatives carry aerosol risks and device maintenance, while gums or patches lack satisfactiononly 10% of smokers quit fully via NRTs

Food and Drug Administration (FDA) has approved: Four nicotine replacement therapies (NRT): transdermal patch* gum* lozenge* nasal spray Two non-nicotine medications: varenicline bupropion * available over-the-counter (OTC) and covered by Medicaid with a fiscal order and some health insurance plans with prescription requires prescription Combination Pharmacotherapy Not all smokers can quit with single-drug therapy

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