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von Euler), Karolinska Institutet, Stockholm, showed that 4-methylnicotine exerted a very low pharmacological activity in all the tests used 1 while that of 6-methylnicotine was fairly strong The stimulating effect of 6-methylnicotine on the isolated guinea-pigs ileum was 25% stronger than that of natural nicotine

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CONCLUSIONS Our findings indicate that Singapores standardized packaging mandate is associated with positive quit-related outcomes, reduced attractiveness of tobacco products, brand distinction and the perceptions that some brands are less harmful, and increased effectiveness of graphic health warnings.