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To be classified as a probiotic, the strain must be non-pathogenic, non-toxic, free from transferable antibiotic resistance genes, adequately characterized, tested for safety and technical characteristics for the intended use, maintain a viable population throughout its shelf life, and be proven to confer health benefits (Hill et al., 2014)

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Nature 454 (7201), 232235

Longitudinal analysis of adolescents at high risk of depression: prediction models