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References: Yakar, S et al., 40 YEARS OF IGF1: Insulin-like growth factors: actions on the skeleton (Jul 2018)

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In this study, we investigated the influence of IGF-1/IGF-1R/ hsa-let-7c axis on the proliferation and differentiation of human SCAPs, and found that IGF-1/IGF-1R/ hsa-let-7c axis can affect the odonto/osteogenic differentiation of SCAPs during which JNK and p38 MAPK signaling pathway were involved

It is frequently driven by a disconnect between the brains signaling and the bodys response