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As for AOD9604, given it does not possess the negative side effects of HGH, it already has a great start with respect to safety

Growth hormone is the main example

In vivo mouse studies at 20 mg/kg subcutaneous, three injections per day for 11 days, produced reductions in body weight, white adipose mass, and adipocyte size

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Additionally, estrogen promotes cardiovascular health by reducing low-density lipoprotein, increasing high-density lipoprotein, improving glucose metabolism, decreasing insulin, protecting against atherosclerosis, and improving blood vessel response to injury