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Short-term withdrawal symptoms (irritability, cravings, restlessness, difficulty concentrating) typically peak within the first week and subside substantially by week four [4]

.MaldonadoJ.MolinaI.Gonzlez-DazY.et al (2017)

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Another downside of combining these substances is while Vyvanse enhances focus and reduces hyperactivity, cannabis can cause problems with focus and ruin the benefits of Vyvanse

and the replacement reward effect brought by vaping itself

Carbon monoxide, hydrogen cyanide, and hydrogen sulfide can do this