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We may assume the possible mechanism of detrimental effect of smoking on CF may be because the alterations in microbiome due to airway surface liquid secretion, enhanced mucus expression, reduced mucociliary clearance induced by loss of CTFR functions

A single 4 mg dose of nicotine decreases heart rate variability in healthy nonsmokers: implications for smoking cessation programs

However, even this category is under scrutiny, as states like California expand definitions to include "tobacco product flavor enhancers" and synthetic nicotine

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The biggest concern is around having an uncomfortable time, especially if you dont have much experience with either substance