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Food and Drug Administration has noted that nicotine is most harmful when delivered through smoke particles from traditional cigarettes and that it is the toxic mix of chemicals in that smoke not nicotine that cause the serious health effects among those who use tobacco products, including fatal lung diseases like chronic obstructive pulmonary disease (COPD) and cancer

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Surgeon General stated in 2010 that there is no safe level of exposure to tobacco smoke

J Gen Intern Med [Internet]

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