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"Now he's gone and joined that stupid club," O'Connor told a reporter at the time, referring to the grim 27 Club, which includes other musicians felled at the identical age, including Jimi Hendrix, Janis Joplin, Jim Morrison and, later, Amy Winehouse

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Nevertheless, PCP misuse continues to this day

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However, while the inverse age gradient that increased over the period was also apparent in non-vapers, it was more pronounced among vapers (Additional file 1: Fig