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Decades before the rugged Marlboro Man image was born, Marlboros were a cigarette aimed at women, with their ad campaign focused around high-class ladies elegantly smoking, alongside assurances that Marlboros wouldnt interfere with a womans lipstick

Using a Heraeus Labofug centrifuge (Thermo Scientific, PA, USA), all green- and red-capped tubes were centrifuged once at 4400g for 5 min at room temperature, whereas blue-capped tubes were centrifuged twice at 2000g for 15 min

Dr Greg Hartwell, from the London School of Hygiene and Tropical Medicine, said the team discovered "consistent evidence around transitions to smoking which of course, in turn, opens the door to the multitude of harms that conventional cigarettes bring"

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Author Contributions Conceived and designed the experiments: KC PAM

Among them are write-ups of experiments on rats, dogs, and rabbits showing that C8 was associated with a wide range of health problems that sometimes killed the lab animals