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This dimeric form of Prx2 is non-functional, but the disulfide bridge between the subunits can be broken by Trx, regenerating Prx2, and completing the catalytic cycle [73]

Repurposing metformin for the prevention of cancer and cancer recurrence

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doi: 10.3390/ijerph20156461 [DOI] [PMC free article] [PubMed] [Google Scholar] 104.Canhada SL, Vigo , Giatti L, Fonseca MDJ, Lopes LJ, Cardoso LDO, et al