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Impressionists like Vincent van Gogh, who was a pipe smoker himself, would also begin to associate smoking with gloom and fin-du-sicle fatalism

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A3: Smoking reduces lung function by causing inflammation and irritation in the airways

Rustica is much better suited to the cooler sections of North America, easily reaching maturity from outdoor seed-grown plants, while tabacum is a far less reliable producer of viable seed if direct sown