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The first study examined dogs affected by myxomatous mitral valve disease and found that individuals living in households with smokers exhibited statistically significantly lower plasma concentrations of tetrahydrobiopterin (p=0.01) [a cofactor for endothelial-derived vasodilator nitric oxide, whose depletion is associated with oxidative stress], suggesting that passive smoke exposure may contribute to oxidative imbalance 37
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The base solution consisting of glycerol and propylene glycol was not found to be cytotoxic at any concentration.48 These results seem to suggest that the toxic effects of electronic cigarettes could be elicited by the added flavours
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