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An alternative hypothesis is depicted on the right, in which inhalation of chemicals common in e-cigarette aerosols (propylene glycol, glycerin, nicotine, or THC) alters the inflammatory state of the lungs, including changing alveolar macrophages to a proinflammatory phenotype with the release of inflammatory cytokines (indicated by yellow circles), such that a second hit causes a pathologic inflammatory response

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"I was a smoker for seven years, and I vaped for two, and now I don't smoke or vape, but it's good Walmart takes it all off." Another shopper showed the tiny device he uses to vape nicotine, and said he doesn't worry about lung ailments