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Important note: Liver blood tests (liver function tests, or LFTs) can be entirely normal in people with NAFLD and do not reliably indicate the severity of liver scarring (fibrosis)

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This review explores the contribution of nicotine and obesity to the development of NAFLD and its molecular underpinning

Decisive evidence that increased adipose tissue lipolysis contributes to nicotine plus HFD-induced hepatic steatosis derives from studies showing that acipimox, an inhibitor of adipose tissue lipolysis, treatment significantly prevented nicotine plus HFD-induced increase in hepatic TG levels and hepatic steatosis (Figure 2) (42)

It can also negatively affect the entire body, causing lung and stomach problems, increasing blood pressure and heart rate, and narrowing arteries, which can lead to a heart attack

Exacerbation of Existing Conditions: For individuals with hepatitis B or C, smoking accelerates liver damage, increasing the risk of cirrhosis and liver cancer