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Heavy smokers typically consume 20+ cigarettes daily, while non-dependent smokers consume fewer than 10 cigarettes per day

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To derive the GRS, we used a classic method 26 which consists of computing GRS based on a subset of SNPs exceeding a specific GWAS association P -value threshold (i.e., P 5.0 10 8 in Liu et al

Unsatisfactory risk factor control and high rate of new cardiovascular events in patients with myocardial infarction and prior coronary artery disease