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"Lines and wrinkles usually appear first in areas where we have the thinnest skin and where we have muscles that we use repeatedly, so this explains why we often get our first lines and wrinkles around the eyes and mouth." Additionally, genetics and our lifestyle choices can also play a part in developing lines around the lips

Valavanidis A, Vlachogianni T, Fiotakis K: Tobacco smoke: involvement of reactive oxygen species and stable free radicals in mechanisms of oxidative damage, carcinogenesis and synergistic effects with other respirable particles