Nicotine pouches do not contain tobacco and most use nicotine extracted from tobacco, while some use synthetic nicotine.* Nicotine pouches can vary in strength to cater to a users preference
Physical symptoms tend to be strongest here: muscle and joint pain, nausea, sweating, chills, rapid heartbeat, and significant insomnia
Hebrews 13:17 (ESV) 17 Obey your leaders and submit to them, for they are keeping watch over your souls, as those who will have to give an account
PMID 10529022
These coefficients are then applied to observed excess lung cancer (above never-smoker rates) to estimate the fraction of deaths from other causes attributable to smoking, without requiring direct data on smoking prevalence
Carelessly dumped CAT filters are certainly part of the problem