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HLA-C*05:01 and HLA-C*04:01 share similar peptide preferences at p3 for Asp and conserved hydrophobic residues at the C-terminus, but differ significantly at p2 with HLA-C*04:01 preferring large aromatic residues (Phe, Tyr and Trp) and HLA-C*05:01 preferring smaller residues such as Ala and Ser (Fig

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