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For example, a study on macrophage FAS found that IL-4 can activate sterol regulatory element-binding protein 1 (SREBP1), triggering the de novo lipogenesis (DNL) program, separating it from the cells antioxidant defense by depleting NADPH, thus increasing ROS levels

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The raw transcriptome data have been deposited in the Genome Sequence Archive (GSA) under project number CRA027654 (mouse tissue) and can be accessed at References Cao, Y

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