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There is insufficient clinical trial data to confirm their efficacy and safety in humans

The peptides ability to cross the blood-brain barrier and affect central nervous system tissue remains partially characterized but has generated interest in neurological applications

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doi: 10.1038/nrrheum.2016.18 120 ZhangB

In my clinical experience, patients with tendinopathy lasting 6-24 months often report: Significant pain reduction by week 2-3 Improved load tolerance during physical therapy by week 4-6 Return to prior activity levels (with appropriate rehab) by week 10-14 Ligament Injuries Partial ligament tears (ankle sprains, knee MCL/LCL sprains, wrist sprains) often leave residual instability and chronic pain

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