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While delivery methods differ, nicotine affects the brain in similar ways across all forms, reinforcing use and increasing dependence over time

Neither heat-not-burn nor vaping is safe in an absolute sense

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1993 Nicotine addiction

Monitoring that starts pre-cessation and continues for a few weeks post-cessation may help to distinguish temporary nicotine withdrawal symptoms from a relapse of mental illness and, for those taking medication, can track common adverse side-effects that can increase with quitting (Segan 2017)