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Description

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26, 27, 28 In these studies, the mean concentration of reduced glutathione (GSH), the primary intracellular antioxidant and redox buffer, was found to be significantly decreased, whereas oxidized glutathione disulfide (GSSG) was significantly increased, resulting in a decrease in the glutathione redox ratio (GSH/GSSG) in both plasma and primary immune cells from children with autism

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The strong metal binding affinity of the imidazole ring on the histidine side chain brings oxidizing species close to the substrate methionine (6)

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and L.R.S.F

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doi: 10.1371/journal.pone.0119661 75 MeerenA

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