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They sparked a surge of interest in Indigenous practices and the spiritual and therapeutic applications of hallucinogens

Last year, Canada became the first large country to legalize recreational cannabis

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Multivariable results on the number of different substances used/misused After controlling for covariates (Table 4), the number of different substances used or misused in the past year was 2342% lower among adults who initiated substance use in adulthood than among those who initiated earlier (incidence density ratio (IDR) range=0.580.77, 95% CIs=0.530.79)