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Decreased NAD + levels can contribute to sirtuin mediated deacetylase-dependent alterations in both mitochondrial electron transport activity (resulting in increased production of reactive oxygen species, ROS) as well as to increased nuclear DNA damage leading to the activation poly-ADP-ribose polymerases (PARP)

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Moreover, measures of BMI, changes in seizure severity, and number of ASMs demonstrated no significant differences across all timepoints between the carnitine profiles

Levels of the reduced glutathione (GSH) are maintained via two ATP-consuming steps, involving c-glut-amylcysteine synthetase (cGCS) and glutathione synthetase

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