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Evidence from a multicenter, long-term cardiovascular outcome trial demonstrated that GLP-1RAs reduce mortality associated with cardiovascular disease and confer protective effects by decreasing the incidence of myocardial infarction and nonfatal stroke

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In published Phase 3 trials, mean weight loss for retatrutide at 80 weeks (28.3%) exceeded the mean for tirzepatide in SURMOUNT-1 at 72 weeks (22.5%)

AMPK Activation By reducing post-meal blood sugar spikes, Acarbose maintains a metabolic state that promotes AMPK activation, supporting autophagy and other processes associated with health and longevity

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