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Treatment should be individualized to accommodate heaviness of smoking and any outstanding disease states like acute coronary syndromes and cardiovascular disease. She also notes that studies have found that combination therapies, such as using bupropion hydrochloride or varenicline together with nicotine replacement, are more effective than any single therapy used on its own

In addition, the dual-map showed an intuitive, and easy to interpret the representation of citations made by a wide variety of journals and cited journals (38), providing an explicit gateway to integrate the citing and cited clusters which included four and five major subjects, respectively

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