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The chondrocytes were re-suspended after centrifugation and cultured in 25 cm 2 culture flasks in complete DMEM/F12 with 10% FBS (Gibco, USA) and 1% antibiotic/anti-mycotic solution (Sigma-Aldrich, USA) in 5% CO 2 at 37C

Moreover, the SURPASS programme demonstrated that tirzepatide 15 mg is more efficacious in glycaemic control for people with T2D compared to insulin therapies as well as GLP-1 mono-agonists including semaglutide 1 mg and dulaglutide 1.5 mg

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Previous studies showed that NF-B (p65) knockdown could significantly reduce the expression of MMPs and inflammatory factors in chondrocytes that were treated with IL-1 and TNF- 51

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A drug in development and undergoing clinical trials could be considered prohibited if it falls into one of the categories of banned substances on the WADA Prohibited List, or if it has the potential to be performance enhancing