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Clinically, bipolar disorder often initially presents with a major depressive episode, with its defining feature, mania, only emerging after months or years, resulting in considerable delays 5

Lastly, the bipolar disorder GWAS has a relatively low number of associated loci and a smaller sample compared with the smoking GWAS

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Mucociliary clearance Smoking decreases the ciliary action in the tracheobronchial tree, resulting in impaired clearance of respiratory secretions, chronic cough, and frequent respiratory infections

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The Food and Drug Administration also upped its scrutiny of a number of key aspects of Juuls business, telling the company to turn over documents on its marketing, educational programs and nicotine formula