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In the final model, we included a spline on age, random slope on age by study and the bias covariate encoding exposure definition (that is, current, former and ever smokers), which was picked by the variable selection algorithm 28,29

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Dilute 1/2 cup (120 ml) of the product in 1 gallon (4 L) of water

Both reduce cravings and blunt the psychological symptoms of withdrawal