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Systemic nicotine administration results in dopamine release in the nucleus accumbens (93), an effect shown to be mediated by 2* nAChRs in the ventral tegmental area (92, 94)

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To date, there are only three FDA-approved smoking cessation therapies, the lawmakers wrote

Smoking is often characterized as an all-or-nothing activity -- on doctor's office questionnaires it's usually a yes-or-no question, for instance -- but by some estimates, anywhere from one-fifth to one-third of adults who smoke don't light up every day