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38 Similarly, a GWAS of over 60,000 smokers of European descent found an association between CPD and a SNP in CYP2A6 that is linked to a variant that codes for a non-functional enzyme, CYP2A6*2

Variable CYP2A6-mediated nicotine metabolism alters smoking behavior and risk

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The main effect of these is increasing the surface area, which boosts both flavour and vapour production

Bibcode:2020Sci...369.1455L

"Part of it is I don't know where I fit in the celebrity culture because [I think] I'm a D-list country singer and I find myself in a room with A-list people and I don't know how to navigate it or how to talk to them," she told People