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3 Metabolic drivers of macrophage dysfunction in COPD The increase in both total and polarized AMs may drive COPD pathogenesis through multiple mechanisms, including the secretion of proinflammatory cytokines, chemokines, and MMPs, along with impaired phagocytic and bactericidal functions (75)

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sated) smokers, the resting state functional connectivity (rsFC) strength in an amygdala-insula-Default-Mode Network (DMN) circuit was downregulated following NRT administration, suggesting relief of the reported subjective withdrawal state

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