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Consequently, UNC10088 promotes ubiquitination of the NSD2 PWWP1 domain by SCF FBXO22 in the presence of different combinations of ubiquitin-carrying enzymes (UCEs), E2s (UBE2D2, UBE2L3, UBE2R2) and the ARIH-type of RBR (ARIH1) (Fig

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Cancer cells bypass glutamine metabolism involved in drug resistance Glycolysis In instances where the metabolic process of glutamine is impeded, glycolysis can emerge as a compensatory pathway, contributing to the emergence of drug resistance

Given the role of LoF mutations in ASD etiology, many of the therapeutics in development are designed to rescue the haploinsufficient effect of genes at the transcriptional, translational, and protein levels

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