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Repurposing of metformin and aspirin by targeting AMPK-mTOR and inflammation for pancreatic cancer prevention and treatment

A study in healthy adults showed that oral glucose loading reduced GH response to GHRH by 75% compared to fasted conditions (Giustina & Veldhuis, Endocr Rev 1998)

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6.2 Candidate prioritization: recurring signals from correlational evidence Although Level C studies constitute the majority (76%) of the included literature and cannot independently establish causality, they provide a rich repository of recurring signals that serve as a roadmap for future hypothesis testing