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Significant weight loss typically occurs over several months, with clinical trials showing average weight reductions of 15% or more

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The European Medicines Agency has called for semaglutide labels to be updated to list NAION as a very rare side effect and has urged patients to seek urgent medical attention for sudden vision changes

The dual primary endpoints were change in KCCQ-CSS (a standard measure of heart failure-related symptoms and physical limitations) and percentage change in body weight from baseline to 52 weeks