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Animal studies used 10 mcg/kg daily dosing via intraperitoneal injection, which scales allometrically to approximately 100150 mcg daily in humanssignificantly lower than anecdotal doses reported in athletic communities

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Similarly, quality of life, as assessed by the SF-36 (one patient had a total of four data points missing), showed significant improvements from baseline in the active treatment group for pain and physical functioning in contrast to the placebo group (Figure 6)

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However, arthroscopy and magnetic resonance (MR) arthrography, despite their efficacy, present certain drawbacks, such as invasiveness, prolonged procedural durations, high cost and being operator dependent (8,12-14)