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TLFB reports collected during self-monitoring appeared to be an improvement over Global reports, and have some validity, but the data also suggested the limits of TLFB, and favored the validity of EMA data, both with regard to digit bias, and also as validated by objective biochemical markers of smoking

Abstract Rationale Cigarette smoking is one of the leading preventable causes of premature death worldwide

If these factors are associated with both e-cigarette use and combustible tobacco cigarette smoking initiation and are not in the causal pathway, they could statistically bias the study results and create a spurious effect of e-cigarette use on a combustible tobacco cigarette use outcome

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