These substances can have immediate effects on the central nervous system but can also cause serious long-term damage with regular use
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The World Health Organizations Framework Convention on Tobacco Control (FCTC) defines smokeless tobacco as tobacco that is consumed in unburnt form either orally or nasally 2

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The chemicals in tobacco smoke and e-cigarette vapour can cause mutations in the cells of the mouth, leading to cancerous growth
A cigarette contains one to two milligrams of nicotine, while a cigar contains 100 to 200 milligrams