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Upon randomization, the subjects were instructed to use their randomized product a minimum of six times (two times on the first 0.5 day and four times on the second day) to provide familiarity with each product (except for UB cigarette) prior to the corresponding clinical Test Session

Video from the American Lung Association

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The increased blood pressure in the arteries causes the lungs to become narrow (or constrict), thereby reducing blood flow through the lungs and causing low levels of oxygen in the blood