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For example, in one study (42 722 people), the relative risk for coronary heart disease among men was 2.74 (one to four cigarettes per day), representing 63% of the excess relative risk for smoking 20-24 cigarettes per day (relative risk 3.75).17 This contrasts with the effects observed for lung cancer in the same study, with relative risks of 2.79 versus 31.69,17 representing 6% of the excess relative risk, consistent with a linear relation between cigarette consumption and riskthat is, 5% of the consumption associated with about 5% of the excess risk, which has also been shown in other large studies.1055 A recent study (290 215 US adults) showed that consistent light smoking throughout a lifetime also has a large excess risk for cardiovascular disease mortality: hazard ratio 2.78 for smoking less than one cigarette per day and 1.50 for one to 10 cigarettes per day, compared with 2.77 and 3.16 for smoking 21-30 and more than 30 cigarettes per day, respectively.80 We have also confirmed that low cigarette consumption is associated with a high risk of stroke

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