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Competing interests RKJ serves as an expert witness in JUUL Labs litigation

Abbreviations 2-AG: 2-Arachidonylglycerol A2A: Adenosine A2A receptor ACE2: Angiotensin converting enzyme 2 AEA: Anandamide ALI: Acute lung injury APC: Antigen-presenting cell ARDS: Acute respiratory distress syndrome cAMP: Cyclic adenosine monophosphate CB1: Cannabinoid receptor 1 CB2: Cannabinoid receptor 2 CBC: Cannabichromene CBD: Cannabidiol CBE: Cannabielsoin CBG: Cannabigerol CBGA: Cannabigerolic acid CBL: Cannabicyclol CBN: Cannabinol CBND: Cannabinodiol CBR: Cannabinoid receptor CBT: Cannabitriol CNS: Central nervous system COPD: Chronic obstructive pulmonary disease COVID-19: Coronavirus-induced disease-19 DC: Dendritic cell eCO: Exhaled carbon monoxide ECS: Endocannabinoid system EVALI: The e-cigarette product use associated lung injury FAAH: Fatty acid amide hydrolase G i : G-inhibitory alpha subunit GPCR: G-protein coupled receptor G : G beta-gamma dimer IBD: Inflammatory bowel disease IFN: Interferon HIV: Human immunodeficiency virus K i : Inhibitory constant IM: Interstitial macrophage LPS: Lipopolysaccharide MEP: Methylerythritol phosphate M1: Classically activated macrophages M2: Alternatively activated macrophages MAGL: Monoacylglycerol lipase MAPK: Mitogen-activated protein kinase MCP-1: Monocyte chemoattractant protein-1 MMP: Matrix metalloproteinase MS: Multiple sclerosis NF-B: Nuclear factor kappa-light-chain-enhancer of activated B cells NK: Natural killer cell NO: Nitric oxide PBMC: Peripheral blood mononuclear cells PK: Pharmacokinetics PKA: Protein kinase A PPAR: Peroxisome proliferator activated receptor ROS: Reactive oxygen species SARS-CoV-2: Severe acute respiratory syndrome-coronavirus-2 T1D: Type 1 diabetes Th1: T-helper type 1 Th2: T-helper type 2 TLR: Toll-like receptor T reg : Regulatory T cell TRP: Transient receptor potential channel 9 -THC: Delta-9-tetrahydrocannabinol 9 -THCA: Delta-9-tetrahydrocannabinolic acid VEA: Vitamin E acetate References Small E

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As per the survey of Japanese adolescents and adults, 48.0% of respondents were aware of heat-not-burn tobacco products

Others may have difficulty breathing, cough up black mucus and experience chest tightness