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The table's thyroid cancer history row says risk of recurrence with rapid weight loss or hormonal shifts requires oncology consultation, with oncology sign-off recommended

It is a fundamental gap in efficacy driven by the dual-receptor mechanism

Originally developed and positioned as treatments for type 2 diabetes, these agents are now equally associated with weight management, reshaping how clinicians, patients, and pharmacies understand metabolic disease

1953 James Watson and Francis Crick publish the double-helix model of DNA, revolutionizing our understanding of genetics and laying the foundation for modern molecular biology