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They framed the gutbrain axis as a dynamic bidirectional signaling network whose dysregulation underlies a broad spectrum of neurogastrointestinal diseases, positioning EVs as key mediators of intercellular communication and promising non-invasive biomarkers Derived from both host and microbial cells, EVs carry bioactive cargo, including proteins, lipids, nucleic acids, and metabolites, that reflects the physiological or pathological state of their origin and can traverse biological barriers such as the bloodbrain barrier

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Mol Neurobiol 55(4):30073020 Liu Y, Wang L, Pan D, Li M, Li Y, Wang Y, Xu Y, Wang X, Yan J, Wu Q, Lu L, Yuan K, Yang M (2021) PET evaluation of light-induced modulation of microglial activation and GLP-1R expression in depressive rats